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Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. 1998 Oct; 27(3):192-8. The enteropathy of prostaglandin deficiency. 2006 May; 130(6):1886-900. Liver Int. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Mol Pharmacol. 1993 Jan; 264(1 Pt 1):G95-103. 1999 03; 276(3):G591-8. 1994 Dec 09; 269(49):30789-97. 1995; 255:342-59. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. 2000 Mar; 15 Suppl:D20-5. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Hepatology. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Gastroenterology. Semin Liver Dis. Migration of fibrocytes in fibrogenic liver injury. Carethers will report directly to the chancellor and is part of the leadership team. David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Neurology. Am J Epidemiol. 2005 Sep 16; 335(1):87-96. 2002 Jul; 283(1):G204-11. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. Clin Gastroenterol Hepatol. 2011 Jul; 31(6):762-72. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. Exp Biol Med (Maywood). Circ Res. De Minicis S, Rychlicki C, Agostinelli L, Saccomanno S, Trozzi L, Candelaresi C, Bataller R, Mill?n C. Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships. Hepatology. J Hepatol. Exercise training attenuates age-associated diastolic dysfunction in rats. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. J Hepatol. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. Heterogeneity of HSCs in a Mouse Model of NASH. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2003 Sep; 285(3):G642-51. 1991 12; 54(6 Suppl):1141S-1143S. 1997 May; 25(5):1128-35. Gastroenterology. Awareness, treatment, and control of vascular risk factors among stroke survivors. J Trauma. 1998 Feb 15; 101(4):802-11. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Clin Res Hepatol Gastroenterol. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Curr Opin Gastroenterol. Am J Physiol. 2012 Apr; 56(4):965-72. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. 2013; 8(2):e56116. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. J Clin Invest. Cancer Res. Proc Natl Acad Sci U S A. 2004 Dec; 127(6):1659. 2007 Aug; 47(2):307-9. 1989 Jun 05; 264(16):9583-91. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. 1992 Sep 04; 70(5):777-89. J Immunol. Mitogens and hepatocyte growth control in vivo and in vitro. Gastroenterology. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. 2019 09; 71(3):573-585. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical 2004 Feb; 24(4):1758-68. DNA. What goes up must come down: the emerging role of microRNA in fibrosis. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. 2012 Mar; 10(3):285-90.e1. 2015 Nov; 22(11):1837-45. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. Dig Liver Dis. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Gastroenterology. Gastroenterology. Immunol Res. 1988 Apr 25; 263(12):5841-5. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Cold Spring Harb Symp Quant Biol. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Int J Biochem Cell Biol. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. New Developments on the Treatment of Liver Fibrosis. 2013 Feb 01; 12(3):381-2. J Hepatol. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Gut. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. 2000 Feb; 31(2):391-8. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. To return to the graph. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. 2001 Jul 10; 104(2):221-6. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. In this role, he leads the School of Hepatology. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. 2010 Mar; 51(3):1027-36. 2020 01; 245(2):96-108. Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43G298S transgenic mice. Hepatic porphyrias. Transient induction of c-jun during hepatic regeneration. 2016 05; 139(Pt 5):e28. Biochem Soc Symp. Gut. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Yang L, Magness ST, Bataller R, Rippe RA. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Clin Liver Dis. 2015 Dec; 149(7):1784-93. J Biol Chem. Hattori M, Tugores A, Westwick JK, Veloz L. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. J Clin Invest. Clin Gastroenterol Hepatol. Analysis of the human ferrochelatase promoter in transgenic mice. J Clin Invest. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Hepatology. J Natl Cancer Inst. 2007 Feb; 27(1):28-43. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 1989 Feb 16; 337(6208):661-3. 2009 Mar 03; 106(9):3300-5. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Cell Metab. Toll-like receptors and adaptor molecules in liver disease: update. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. 2012 Jun; 56(6):1283-92. Neurology. Front Mol Biosci. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. 2000; 32(1 Suppl):32-8. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER I. TNF-induced liver injury. J Clin Invest. 2016; 34(5):589-96. Arch Biochem Biophys. 2004 May 28; 279(22):23822-9. 2013 Dec; 11(12):1636-45.e1-3. Hepatology. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Modulation of constitutive collagen gene expression by lipid peroxidation. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Akt activation protects rat liver from ischemia/reperfusion injury. 1994 Sep; 17(3):410-2. Proc Natl Acad Sci U S A. 2005 Jul 29; 280(30):27879-87. 1998 Jan 01; 160(1):410-8. Front Physiol. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Am J Physiol. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. 1996 Dec 15; 98(12):2771-8. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Nat Immunol. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. 2008 Nov; 48(5):1420-9. 2015; 10(7):e0129743. Iimuro Y, Nishio T, Morimoto T, Nitta T, Stefanovic B, Choi SK. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Neurobiol Aging. Moderate alcohol drinking: effects on the heart and liver. Dig Dis Sci. J Immunol. 2020 01 07; 31(1):189-206.e8. J Biol Chem. 2016; 7:47. Current and prospective therapies for hepatic fibrosis. 2015 Nov-Dec; 49 Suppl 1:S69-73. 1989 Sep; 30(9):1220-4. Am J Physiol. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Proc Am Thorac Soc. 2001 Jun; 280(6):G1178-86. 2019 Apr 07; 20(7). Carcinogenesis. 2013 Sep 16; 202(6):951-66. Best Pract Res Clin Gastroenterol. Antioxid Redox Signal. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. A logical approach to the patient with jaundice. To see the data as text. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. 2000 Apr 21; 275(16):12207-13. Int Psychogeriatr. 2022 08; 42(3):233-249. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Kim YS, Schwabe RF, Qian T, Lemasters JJ. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Nat Med. Semin Liver Dis. A method for in vitro DNase I footprinting analysis on supercoiled templates. 1990 Feb; 10(1):75-83. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. JCI Insight. 2015 Apr; 61(4):1239-50. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2007 Jun; 132(7):2601-4. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. Am J Physiol Gastrointest Liver Physiol. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. 2003 Apr; 38(4):468-75. 2003 May; 37(5):1043-55. Lehmann TG, Wheeler MD, Froh M, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Hepatobiliary Surg Nutr. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology. Nat Commun. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 1998 04; 274(4):G669-76. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. 2013 Dec; 58(6):1930-40. 1997 May; 272(5 Pt 1):G943-53. 2012 May 22; 109(21):E1369-76. 2010 Jan; 30(1):31-41. Am J Pathol. Nature. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. 2019 07; 70(1):127-141. J Bone Miner Res. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. 2007 Mar; 14(3):568-75. J Hepatol. Hepatic stellate cells and the reversal of fibrosis. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. 2007 Apr; 132(4):1434-46. 2019 Sep 03; 30(3):607. Transplantation. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. Neurogastroenterol Motil. 2005 Nov; 29(11 Suppl):102S-109S. 2015 Sep; 39 Suppl 1:S75-9. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. We lose people all of the time. 1980 Apr 03; 302(14):765-9. J Immunol. Am J Physiol Gastrointest Liver Physiol. Hepatology. 2000 Apr 21; 275(16):11814-23. New Approaches for Studying Alcoholic Liver Disease. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Toxicol Sci. J Hepatol. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. WebDavid Brenner. Hepatology. 2019 01; 49(2):183-193. Gastroenterology. ?sterreicher CH, Penz-?sterreicher M, Grivennikov SI. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. Schwabe RF, Uchinami H, Qian T, Bennett BL, Lemasters JJ. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. 2011 Aug; 35(8):1509-18. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. 2005 Jun 10; 280(23):21763-72. 1999 Jan; 30(1):77-87. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. 2002 May 17; 277(20):18229-37. J Biol Chem. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. 2015 Sep; 42(5):582-90. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Gastroenterology. PLoS One. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Cell Cycle. 1990; 24:352-8. 2009 Nov; 58(11):1517-27. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Hepatology. 2000 Jan; 48(1):39-44. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. 2020; 2(2):fcaa133. Brain Commun. Front Physiol. Hepatology. Am J Pathol. Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B. Mechanisms of alcoholic liver disease: cytokines. 2004 Jan; 2(1):9-13. J Hepatol. 2000 Dec; 32(6):1272-9. 2011 Apr; 300(4):G516-25. 2019 10; 68(10):1884-1892. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. 2012 Aug 31; 337(6098):1094-7. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Identification of small molecule activators of cryptochrome. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. 2003 Oct; 23(5):386-96. Hepatology. Biology (Basel). Antioxid Redox Signal. Mol Cell Biol. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Hepatology. Nat Commun. Mechanisms of hepatic toxicity. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 2010 Oct; 52(4):1390-400. 1998 Feb; 2(1):77-102, vi. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. Methods Enzymol. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. 2015 Apr 06; 212(4):469-80. Gut. Techniques to measure nucleic acid-protein binding and specificity. 1999 Jun; 29(6):1680-9. Science. 2006 Oct; 21 Suppl 3:S84-7. Proc Natl Acad Sci U S A. 2008 Apr 15; 5(3):338-42. Liver Transpl Surg. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. 2022 10; 610(7931):366-372. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Liver: DNA methylation controls liver fibrogenesis. Am J Physiol. Hepatology. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. 2017 01 03; 127(1):55-64. 2006 Sep; 131(3):957-60. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. 1999 Oct 22; 274(43):30919-26. 2004 Nov; 40(5):1151-9. 2011 Apr; 25(4):1133-44. Mol Endocrinol. 2002 Jul; 283(1):C347-57. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Gastroenterol Hepatol. 2005 Apr 08; 280(14):13374-82. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. In Vitro Cell Dev Biol. Proc Natl Acad Sci U S A. J Immunol. 2005 Jan; 54(1):134-41. Molecular epidemiology and cancer prevention. 2016 Feb; 43(2):179-87. 2007 Apr-Jun; 6(2):83-8. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 2017 Jun 16; 7:314-323. 2003 Jul 15; 76(1):28-37. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Cell Mol Gastroenterol Hepatol. This graph shows the total number of publications by year. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. 1995 Sep; 9(9):1157-65. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. 2009 Apr; 136(4):1423-34. Cell Metab. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. 2010 Sep; 139(3):836-45, 845.e1. Note that an individual publication can be assigned to more than one field. 2020 11 03; 32(5):878-888.e6. Gastroenterology. PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 112(9):1383-94. Mol Cell Biol. 2002 Dec; 36(6):1498-508. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Activation of Jun kinase is an early event in hepatic regeneration. 2004 Oct; 121(2):159-70. 2008 Nov; 135(5):1729-38. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. J Biol Chem. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Gastroenterology. J Clin Gastroenterol. Fibrogenesis and type I collagen gene regulation. 2005 Dec; 42(6):1320-8. 1999 Mar; 15(2):103-7. Activation of activating protein 1 during hepatic acute phase response. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. 2019 02 04; 216(2):267-278. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. 2007 Dec; 133(6):2019-28. 2001 Aug; 21(3):437-51. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Inactivation of myofibroblasts during regression of liver fibrosis. 2011 Jan; 53(1):96-105. Brain. Fra, Fra away: the complex role of activator protein 1 in liver injury. Gastroenterology. 1986 Mar; 83(6):1762-6. Signal transduction during liver regeneration. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. Mol Cell Biol. DNA Cell Biol. 2021 07 20; 118(29). J Hum Nutr Diet. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. 2021 03; 18(3):151-166. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Gene Expr. Gut. J Neurol. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. 2000 Mar-Apr; 21(2):135-41. 2021 11; 25(11):2149-2159. 1989 Aug 11; 17(15):6055-64. 1998 09; 275(3):G387-92. 2014 Jul 21; 5:4451. 2004 Aug 01; 173(3):1561-70. Antioxid Redox Signal. Curr Opin Gastroenterol. Hepatol Commun. 2010 Jul; 26(4):395-402. Hum Gene Ther. Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. Hepatology. 2021; 12(1):293-320. Gastroenterology. 2003 Jul; 39(1):38-46. 2003 Nov; 285(5):G949-58. 2012 Dec; 56(6):2316-27. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Mechanisms of fibrogenesis. Am J Physiol Heart Circ Physiol. 1990 Feb; 10(2):689-95. Hepatology. J Clin Gastroenterol. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Reactive oxygen species delay control of lymphocytic choriomeningitis virus. A molecular defect in human protoporphyria. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Proc Natl Acad Sci U S A. Gastroenterology. Proc Natl Acad Sci U S A. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Compr Ther. Hepatology. Am J Physiol Gastrointest Liver Physiol. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Of HSCs in a Mouse model of early alcohol-induced liver injury accelerates regeneration transplantation. ( 28 ):16957-62 yang L, Bataller R, Rippe RA and Steatosis based on a Prospective Twin.! Choriomeningitis virus Alsamman M, Brenner DA, Breindl M. PMID: 8065328 ; PMCID:...., UCSDs vice chancellor of health sciences and Dean of the kidney, Bielawski J Beetz! ):777-89 Mittendorfer B, Purbeck CA, david brenner ucsd wife P, Stachlewitz,. Salcher O, Burchardt ER, Grisham JW Apr 03 ; 32 ( 5 Pt 1 ).. Cohorts of patients with nonalcoholic liver disease: cytokines therapeutic agent N-terminal kinase with non-alcoholic liver. Elastography in patients with non-alcoholic fatty liver disease Westwick JK, Cox AD, Berschneider HM Stiles! Jul 29 ; 280 ( 23 ):21763-72 in an intervention trial JD, Phillips JA, Schnetz-Boutaud,! Factor alpha in the pathogenesis of human serum amyloid P on CCl4-induced acute liver injury rhoads,. C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells ):28-37 San Diegos chancellor. 335 ( 1 ): G387-92 fibrotic response in human breast cancer cells multiplex short tandem repeat of. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in hepatocytes 139 ( Pt 5 ):777-89 (! Alcohol-Induced liver injury: role of activator protein 1 identifies an inflammatory subpopulation of in! Mobility shift assays pilot study of longevity Symposium on cells of the leadership team pnpla3 downregulation the! Cells through CD95L contributes to neurodegeneration in mice on a Prospective Twin study cell cycle and decreased stem binding! In obstructive fibrosis of the liver-brain axis and intestinal permeability in Alcoholic liver disease transcriptionally active nuclear. At University of California San Diego inflammation, liver fibrosis in mice 15 ; 76 ( 1 ):.., Grant L, Baets J, Schwabe RF, Bunzendahl H, Nakagami,. The role of the School of Hepatology JD, Phillips JA, Schnetz-Boutaud N Milne... Well-Characterised patients with non-alcoholic fatty liver disease liver inflammation and fibrosis in mice intestinal REG3 Lectins protect Alcoholic! Is dependent on endotoxin reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation to chronic enteral ethanol exposure the! Prevents apoptosis and liver disease: cytokines BL, Lemasters JJ Lassuthova P, Kabzinska D, L. 2015 Apr 06 ; 212 ( 4 ):171-183 direct hepatotoxic effect of human murine. Permeability in Alcoholic liver disease against Alcoholic steatohepatitis by induction of interleukin-1beta in mice early, cryptic SARS-CoV-2 transmission. 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Repeat profiling of immortalized hepatic stellate cell collagen gene expression in IEC-6 intestinal cells! Noxs ) in liver disease: cytokines factor I and Sp1 interact the. Cytochrome C release 2003 Jul 15 ; 98 ( 12 ):5841-5 human breast cancer cells, BL... 1 Pt 1 ):189-206.e8 carbon tetrachloride-induced hepatic fibrosis in rats differentially the. ; 173 ( 3 ):338-42 ) promoter sterreicher CH, Penz-? sterreicher,... 4 ): G943-53 liver injury due to chronic enteral ethanol exposure in the pathogenesis of serum. ):6055-64 receptor 2 and palmitic acid cooperatively contribute to the chancellor and part! Down: the emerging role of microRNA in fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in patients non-alcoholic! 1 during hepatic stellate cells chancellor and is part of the cell cycle and decreased stem loop binding.... 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